First Successful Insulin Treatment for Diabetes
In the early 1920s, Type 1 diabetes remained a fatal condition with only strict starvation diets offering limited extension of life. Researchers Frederick Banting, Charles Best, and James Collip at the University of Toronto had isolated insulin from pancreatic extracts after years of experimentation. On January 11, 1922, 14-year-old Leonard Thompson, critically ill and weighing about 65 pounds, received the first human injection of insulin at Toronto General Hospital. The initial dose caused an allergic reaction due to impurities, but a refined preparation administered on January 23 dramatically stabilized his blood sugar. Thompson's survival and recovery demonstrated insulin's potential, leading the university to license production royalty-free to pharmaceutical companies.
