Watson and Crick Model DNA Double Helix
In postwar Britain, molecular biology was advancing rapidly with X-ray diffraction data from Rosalind Franklin and Maurice Wilkins at King's College London, alongside Chargaff's base-pairing rules. At the Cavendish Laboratory in Cambridge, young researchers James Watson and Francis Crick competed to solve DNA's structure using model-building and available evidence. On February 28, 1953, Watson correctly oriented the nucleotide bases in their cardboard models following advice on tautomeric forms, revealing the complementary double-helix configuration with sugar-phosphate backbones and specific base pairing. Crick immediately recognized its implications for genetic replication. They announced the breakthrough informally at a pub that evening and published the landmark one-page paper in Nature two months later. The discovery provided the molecular basis for heredity and launched modern...
